These common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 180207-57-2
To a solution of 2-chloro-N-(2,4-dimethoxybenzyl)-5-nitrobenzenesulfonamide (661 mg,1.71 mmol) in acetonitrile (13 mL) were added 2-(1H-pyrazol-4-yl)ethanol (383 mg,3.42 mmol, CAS-RN 180207-57-2) and powdered potassium carbonate (944 mg,6.83 mmol), and the mixture was irradiated for 2h at 140C in the microwave. The reactionmixture was diluted with water and extracted with ethyl acetate. The combined organicphases were washed with brine and dried using a Whatman filter. Concentration underreduced pressure led to the title compound that was purified by flash chromatography (285 mg, 34% yield, 95% purity).LC-MS (Method B): Rt = 1.08 mm; MS (ESIpos): mlz = 463 (M+H)1HNMR (400MHz, DMSO-d6) oe [ppm]: 2.66 (t, 2H), 3.42 (s, 3H), 3.60 (s, 3H), 3.62 (td,2H), 4.17 (d, 2H), 4.75 (t, 1H), 6.11 (d, 1H), 6.26 (dd, 1H), 7.09 (d, 1H), 7.78 (d, 1H), 7.85 (s, 1H), 8.15 (s, 1H), 8.19 (d, 1H), 8.28 (t, 1H), 8.40 (dd, 1H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 180207-57-2.