Application of a multi-SO3H Bronsted acidic ionic liquid in water: a highly efficient and reusable catalyst for the regioselective and scaled-up synthesis of pyrazoles under mild conditions was written by Safaei, Shirin;Mohammadpoor-Baltork, Iraj;Khosropour, Ahmad Reza;Moghadam, Majid;Tangestaninejad, Shahram;Mirkhani, Valiollah;Kia, Reza. And the article was included in RSC Advances in 2012.Application In Synthesis of 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:
An elegant and efficient procedure with exceptionally mild conditions for the regioselective synthesis of pyrazoles by the reaction of various 1,3-diketones and hydrazines/hydrazides using a multi-SO3H Bronsted acidic room temperature ionic liquid as a powerful catalyst in aqueous media has been developed. The ionic liquid was easily separated from the reaction mixture and was recycled and used for at least six consecutive runs without any loss of activity. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Application In Synthesis of 3,5-Dimethyl-1H-pyrazole-1-carboxamide).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application In Synthesis of 3,5-Dimethyl-1H-pyrazole-1-carboxamide
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics