Zinc(II) complexes with heterocyclic ether, acid and amide. Crystal structure, spectral, thermal and antibacterial activity studies was written by Jablonska-Wawrzycka, Agnieszka;Rogala, Patrycja;Czerwonka, Grzegorz;Hodorowicz, Maciej;Stadnicka, Katarzyna. And the article was included in Journal of Molecular Structure in 2016.COA of Formula: C6H9N3O This article mentions the following:
The reaction of zinc salts with heterocyclic ether (1-ethoxymethyl-2-methylimidazole (1-ExMe-2-MeIm)), acid (pyridine-2,3-dicarboxylic acid (2,3-pydcH2)) and amide (3,5-dimethylpyrazole-1-carboxamide (3,5-DMePzCONH2)) yielded three new zinc complexes formulated as [Zn(1-ExMe-2-MeIm)2Cl2] (1), fac-[Zn(H2O)6][Zn(2,3-pydcH)3]2 (2) and [Zn(3,5-DMePz)2(NCO)2] (3). Complexes of 1 and 3 are four-coordinated with a tetrahedron as coordination polyhedron. However, compound 2 forms an octahedral cation-anion complex. The complex 3 was prepared by eliminating of the carboxamide group from the ligand and then the 3,5-dimethylpyrazole (3,5-DMePz) and isocyanates formed were employed as new ligands. The IR and x-ray studies confirmed a bidentate fashion of coordination of the 2,3-pydcH and monodentate fashion of coordination of the 1-ExMe-2-MeIm and 3,5-DMePz to the Zn(II) ions. The crystal packing of Zn(II) complexes are stabilized by intermol. classical hydrogen bonds of O-H···O and N-H···O types. The most interesting feature of the supramol. architecture of complexes is the existence of C-H···O, C-H···Cl and C-H···π interactions and π···π stacking, which also contributes to structural stabilization. The correlation between crystal structure and thermal stability of zinc complexes is observed In all compounds the fragments of ligands donor-atom containing go in the last steps. Addnl., antimicrobial activities of compounds were carried out against certain Gram-pos. and Gram-neg. bacteria and counts of CFU (colony forming units) were also determined The achieved results confirmed a significant antibacterial activity of some tested zinc complexes. From the Δ log CFU values the antibacterial activity of zinc complexes follows the order: 3 > 2 > 1. Influence a number of N-donor atoms in zinc environment on antibacterial activity is also observed In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5COA of Formula: C6H9N3O).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C6H9N3O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics