Derivatives of 1-pyrazole carboxylic acid. I. Synthesis of certain 1-pyrazolecarbonyl chlorides was written by Brzozowski, Zdzislaw;Magielka, Stanislaw. And the article was included in Acta Poloniae Pharmaceutica in 1981.Product Details of 15953-73-8 This article mentions the following:
Fifteen acid chlorides I (R = H, Me, Et; R1 = H, Me, Et, Pr, Bu, PhCH2 Cl; R2 = H and Me) were prepared in 87-98% yield from the corresponding 1H– pyrazoles and COCl2 in PhMe. Three I were converted into the corresponding amides by reaction with NH3(g) in Et2O. The mass spectral fragmentation of 3-ethyl-4-methyl-1-pyrazole carboxamide is presented. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Product Details of 15953-73-8).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 15953-73-8
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics