4-[3(5)-Pyrazolyl]pyridinium salts. A new class of hypoglycemic agents was written by Bauer, Victor J.;Dalalian, Harry P.;Fanshawe, William J.;Safir, S. R.;Tocus, E. C.;Boshart, C. R.. And the article was included in Journal of Medicinal Chemistry in 1968.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:
A series of 4-[3(5)-pyrazolyl]pyridinium salts (I) was synthesized. Many of these compounds display interesting hypoglycemic activity in alloxandiabetic mice; a structure-activity relationship is derived. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).
2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Quality Control of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics