6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1’H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile was written by Ryzhkova, Yuliya E.;Kalashnikova, Varvara M.;Elinson, Michail N.. And the article was included in Molbank in 2022.Application of 401-73-0 This article mentions the following:
In this study, the multicomponent transformation of 5,7-dibromoisatin, malononitrile, and 5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in EtOH at reflux in the presence of sodium acetate was carefully investigated to give a novel title compound I with excellent yield. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Application of 401-73-0).
3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Application of 401-73-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics