Adach, Anna et al. published their research in Polyhedron in 2022 | CAS: 934-48-5

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C6H9N3O

In situ synthesis, crystal structure, selective anticancer and proapoptotic activity of complexes isolated from the system containing zerovalent nickel and pyrazole derivatives was written by Adach, Anna;Tyszka-Czochara, Malgorzata;Bukowska-Strakova, Karolina;Rejnhardt, Piotr;Daszkiewicz, Marek. And the article was included in Polyhedron in 2022.Synthetic Route of C6H9N3O This article mentions the following:

New nickel(II) complexes [NiLS(NCS)2]•CH3CN (1) [Ni(dmpz)2(NCS)2]n (2), where LS is N,N,N-tris(1-(3,5-dimethylpyrazolylmethyl)amine) and dmpz is 3,5-dimethylpyrazole, were isolated in a one-pot synthesis by reacting zerovalent-powered nickel, 1-hydroxymethyl-3,5-dimethylpyrazole (HL1) and 1-carboxamide-3,5-dimethylpyrazole (HL2) as precursors. The complexes were characterized by elemental anal., IR and UV-visible spectra, thermal studies and single crystal diffraction studies. The anti-proliferative activity of the described Ni(II) complexes was studied in vitro against selected human tumor cell lines and normal human cells (fibroblasts). The monomeric complex [NiLS(NCS)2]•CH3CN (1) expressed more potent anti-proliferative activity towards cancer cells with the relevant cytotoxicity, while the polymeric complex [Ni(dmpz)2(NCS)2]n (2) was very toxic towards normal cells and was also characterized by mild inhibitory potency against tumor cells and poor selectivity. 1 Causes massive death of cancer cells due to programmed cell death, apoptosis. The obtained results demonstrated potent cytotoxic activity of the isolated [NiLS(NCS)2]•CH3CN complex combined with strong selectivity towards cancer cells, and the mechanism of its actions included apoptosis. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Synthetic Route of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics