Stypik, Mariola et al. published their research in Pharmaceuticals in 2022 | CAS: 141459-53-2

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine

Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I-Indole Derivatives was written by Stypik, Mariola;Zagozda, Marcin;Michalek, Stanislaw;Dymek, Barbara;Zdzalik-Bielecka, Daria;Dziachan, Maciej;Orlowska, Nina;Gunerka, Pawel;Turowski, Pawel;Hucz-Kalitowska, Joanna;Stanczak, Aleksandra;Stanczak, Paulina;Mulewski, Krzysztof;Smuga, Damian;Stefaniak, Filip;Gurba-Bryskiewicz, Lidia;Leniak, Arkadiusz;Ochal, Zbigniew;Mach, Mateusz;Dzwonek, Karolina;Lamparska-Przybysz, Monika;Dubiel, Krzysztof;Wieczorek, Maciej. And the article was included in Pharmaceuticals in 2022.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:

In this work, a new library of small-mol. inhibitors based on indol-4-yl-pyrazolo[1,5-a]pyrimidine with IC50 values in the low nanomolar range and high selectivity against the PI3Kδ isoform were designed and synthesized. CPL302253, the most potent compound of all the structures obtained, with IC50 = 2.8 nM, is a potential future candidate for clin. development as an inhaled drug to prevent asthma. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine).

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Safety of 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics