A structural study of pyrazole-1-carboxamides by X-ray crystallography and 13C CPMAS NMR spectroscopy was written by Llamas-Saiz, Antonio L.;Foces-Foces, Concepcion;Sobrados, Isabel;Jagerovic, Nadine;Elguero, Jose. And the article was included in Journal of Molecular Structure in 1999.Product Details of 934-48-5 This article mentions the following:
The crystal structures of the 1st two pyrazole N-substituted primary amides (3-Me and 4-bromo) were determined Crystallog. data and at. coordinates are given. The amide groups from the R22(8) H-bond dimeric pattern in all cases, in accordance with the higher rate found for the formation of this pattern in monosubstituted benzamides (81%) compared with the whole group of primary amide structures (34%). These two compounds and four other N-CONH2 pyrazoles were studied by solid state NMR (CPMAS technique). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Product Details of 934-48-5).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Product Details of 934-48-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics