Studies on 3′-quaternary ammonium cephalosporins. IV. Synthesis and antibacterial activity of 3′-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037 was written by Ohki, Hidenori;Kawabata, Kohji;Inamoto, Yoshiko;Okuda, Shinya;Kamimura, Toshiaki;Sakane, Kazuo. And the article was included in Bioorganic & Medicinal Chemistry in 1997.Recommanded Product: 3528-58-3 This article mentions the following:
The synthesis and in vitro antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]cephalosporins bearing various 2-alkyl-3-aminopyrazolium groups at the 3-position are described. Antibacterial activity against MRSA was affected by the nature of the substituent at the 2-position on the 3′-aminopyrazolium groups. Among the cephalosporins prepared in this study, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[3-amino-2-(2-hydroxyethyl)pyrazolio]methyl-3-cephem-4-carboxylate sulfate (FK037) (I) showed extremely potent broad-spectrum activity against both Gram-pos. bacteria including MRSA, and Gram-neg. bacteria including Pseudomonas aeruginosa. The in vivo activity against MRSA of FK037 was the highest of all the β-lactam antibiotics tested. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics