Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators was written by Iino, Tomoharu;Sasaki, Yasuhiro;Bamba, Makoto;Mitsuya, Morihiro;Ohno, Akio;Kamata, Kenji;Hosaka, Hideka;Maruki, Hiroko;Futamura, Mayumi;Yoshimoto, Riki;Ohyama, Sumika;Sasaki, Kaori;Chiba, Masato;Ohtake, Norikazu;Nagata, Yasufumi;Eiki, Jun-ichi;Nishimura, Teruyuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: pyrazoles-derivatives This article mentions the following:
We describe design, syntheses and structure-activity relationships of a novel class of 4,6-disubstituted quinazoline glucokinase activators. Prototype quinazoline leads were designed based on the X-ray analyses of the previous 2-aminobenzamide lead classes. Modifications of the quinazoline leads led to the identification of a potent GK activator I. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Category: pyrazoles-derivatives).
1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics