A mild and efficient method for halogenation of 3,5-dimethyl pyrazoles by ultrasound irradiation using N-halosuccinimides was written by Stefani, Helio A.;Pereira, Claudio M. P.;Almeida, Roberta B.;Braga, Rodolpho C.;Guzen, Karla P.;Cella, Rodrigo. And the article was included in Tetrahedron Letters in 2005.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:
The 4-halo-3,5-dimethyl pyrazoles were synthesized in good yields in short reaction times in the absence of a catalyst by reaction of 3,5-di-Me pyrazoles with N-halosuccinimides (NBS, NCS and NIS) under ultrasound irradiation Finally, the halogenation of pyrazoles with Br2, ICl and I2 was showed in similar conditions. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics