Reactions with nitriles: a novel synthesis of furo[2,3-c]pyrazoles and pyrano[2,3-c]pyrazoles was written by Aziz, Suzan I.;Abd-Allah, Sanaa O.;Ibrahim, Nadia S.. And the article was included in Heterocycles in 1984.Category: pyrazoles-derivatives This article mentions the following:
The title compounds I (R = CN, Bz), II and III (R1 = Ph, p-MeOC6H4, X = NH, O) were prepared in 80-90% yields by treating 4-bromo-3-methyl-2-pyrazolin-5-one (IV) with activated nitriles. Thus, refluxing IV with CH2(CN)2 in EtOH in the presence of piperidine for 3 h gave 85% I (R = CN). In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Category: pyrazoles-derivatives).
4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics