Variable-Field Study of 13C,35,37Cl Residual Dipolar Coupling in the 13C CPMAS NMR Spectra of Pyrazole Derivatives was written by Olivieri, Alejandro C.;Elguero, Jose;Sobrados, Isabel;Cabildo, Pilar;Claramunt, Rosa M.. And the article was included in Journal of Physical Chemistry in 1994.Recommanded Product: 15953-73-8 This article mentions the following:
High-resolution solid-state 13C NMR spectra of the chlorinated derivatives 3,5-dimethyl-4-chloropyrazole, 4-chloro-5-methylpyrazole, and 3,5-bis(4′-chloropyrazol-1-yl)-4-chloropyrazole [I (R = Me, H) and II, resp.] were recorded at 100.6 MHz (B0 = 9.4 T) and at 50.3 MHz (B0 = 4.7 T). The signals of the carbons bonded to chlorine appear as doublets at 9.4 T and as broad triplets at 4.7 T, due to incompletely averaged 13C,35,37Cl dipolar coupling. The line shapes can be successfully simulated assuming typical values for the C-Cl bond distance and 35Cl quadrupole coupling constant (including its sign). In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 15953-73-8
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics