Synthesis and reactivity of enamines in pyridine series was written by Benckova, M.;Vegh, D.;Kovac, J.;Friedl, Z.. And the article was included in Chemical Papers in 1989.Safety of 3-(1H-Pyrazol-3-yl)pyridine This article mentions the following:
The preparation of (E)-RCH:CHNMe2 (R = substituted pyridyl) by the reaction of suitably substituted picolines, lutidines, and collidines with Me2NCH(OMe)2 was described. By the same method enamino ketones derived from acetylpyridines were prepared The rotational barriers of these enamino ketones were measured by dynamic NMR spectroscopy. The enamino ketones were cyclized with N2H4 and NCCH2CONMe2. E.g., (E)-R1COCH:CHNMe2 (R1 = 2-pyridyl) gives pyrazole I and pyridinone II, resp. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Safety of 3-(1H-Pyrazol-3-yl)pyridine).
3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Safety of 3-(1H-Pyrazol-3-yl)pyridine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics