Synthesis of pyrazole (hemi)aminals via the cleavage of saturated aliphatic ether C-O bonds in the presence of ferric halides was written by Govor, Evgen V.;Sanakis, Yiannis;Raptis, Raphael G.. And the article was included in New Journal of Chemistry in 2017.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:
The discovery of reactions using previously considered inert functional groups opens up new paths towards the synthesis of desired products. Solutions of mononuclear ferric-pyrazole complexes react with di-Et ether cleaving a C-O bond to form chelating hemiaminals. Upon exposure to diffuse light, the latter react further to yield mononuclear ferrous products containing chelating aminals. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics