Reaction of ethyl-4,4,4-trifluoroacetoacetate with cyanoacetic acid hydrazide. Novel rearrangement of 1-aminopyridine derivatives was written by Balicki, Roman;Nantka-Namirski, Pawel. And the article was included in Acta Poloniae Pharmaceutica in 1975.Category: pyrazoles-derivatives This article mentions the following:
CF3COCH2CO2Et (I) condensed with NCCH2CONHNH2 (II) in EtOH in the presence of piperidine (III) yielded 15% IV and an unidentified by-product. The same reaction effected in III without any solvent gave, upon acidification, 70% V. I and II condensed in EtOH with KOH as the catalyst yielded the K salt of VI, which on acidification rearranged to V. Similarly, only V was obtained in the reaction of I with 5-aminopyrazol-3-one. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Category: pyrazoles-derivatives).
3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics