New reaction of 1H-pyrazoles with selenium dioxide: one-pot synthesis of bis(1H-pyrazol-4-yl)selenides was written by Seredyuk, Maksym;Fritsky, Igor O.;Kraemer, Roland;Kozlowski, Henryk;Haukka, Matti;Guetlich, Philipp. And the article was included in Tetrahedron in 2010.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:
A novel reaction between six 3- and 3,5-substituted pyrazoles with Se dioxide proceeds with formation of bis(3R,5R’-1H-pyrazol-4-yl)selenides (R = pyridyl, Ph, Et, Me, H; R’ = Me, Et, H) in 52% to 67% yield. On this basis, an efficient 1-pot synthetic procedure was developed. E.g., reaction of 3-methyl-5-phenyl-1H-pyrazole, SeO2 and pyridine afforded bis(3-methyl-5-phenyl-1H-pyrazol-4-yl) selenide in 67% yield. In the case of the unsubstituted pyrazole a selenonium compound was obtained. The identity and structure of the seven isolated Se derivatives were confirmed by spectral methods and their mol. structures studied by x-ray anal. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).
2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics