Basicity of nitropyrazoles and their simultaneous spectrophotometric determination was written by Dumanovic, D.;Ciric, J.;Muk, A.;Nikolic, V.. And the article was included in Talanta in 1975.Category: pyrazoles-derivatives This article mentions the following:
Uv spectra of nitropyrazoles showed that NO2 shifted the absorption maximum of the neutral mols. and the protonated ionic forms to longer wavelengths by 50-70 nm and 10-30 nm, resp. The basicities of the compounds were compared with those of nitroimidazoles and the NO2 group effects and ortho group effect were determined The effect of NO2 on protonation constants was greater when NO2 was close to the pyridine N. The results indicate that simultaneous spectrophotometric determination of nitropyrazoles is possible. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Category: pyrazoles-derivatives).
1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics