Dorn, Helmut et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1982 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Unambiguous synthesis of 4,7-dihydro-4-oxo-1H-pyrazolo[3,4-b]pyridine – further comments on the “(N-C) rearrangement” of [2-(alkoxycarbonyl)vinylamino]pyrazoles was written by Dorn, Helmut;Ozegowski, Ruediger. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1982.Recommanded Product: 3528-58-3 This article mentions the following:

Successive decarboxylation of pyrazolopyridine I and debenzylation of II (R1 = CH2Ph, R2 = H) with Na in NH3(l) gave the title compound II (R1 = R2 = H). The product from 3-aminopyrazole and HCCCO2Me, formerly described as II (R1 = R2 = H), is the 6-oxo isomer III (R1 = R2 = H). Debenzylation of II (R1 = CH2Ph, R2 = H) and analogs with SeO2 is only possible if the position α to the C:O is blocked; otherwise, selenides of type IV are formed. Cyclizing pyrazoles V (R1 = R2 = H, R1 = CH2Ph, R2 = H, Me; R3 = Me, Et) in acidic media with catalytic amounts the corresponding aminopyrazoles gave pyrazolopyridines III via pyrazoles VI, i.e., via products of a N-C rearrangement, whereas thermal cyclization of V gave II (R1,R2 as above and also R1 = CH2Ph, R2 = Me). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics