Azoles. XIII. Nuclear magnetic resonance spectra of pyrazoles was written by Elguero, Jose;Jacquier, Robert;Nguyen Tien Duc Hong Cung. And the article was included in Bulletin de la Societe Chimique de France in 1966.Electric Literature of C5H7ClN2 This article mentions the following:
The N.M.R. spectra of 180 pyrazoles in nonaqueous solvents (CDCl3, CCl4, C6H6, Me2SO, CF3CO2H) were analyzed. Classes represented were non-N-substituted, N-alkyl (especially N-Me), N-carboxamide, N-tosyl, N-Ph, N-p-nitrophenyl, N-(2,4-dinitrophenyl), and 2,4,6-trinitrophenyl pyrazoles. Chem. displacements (τ) and coupling constants (J) were calculated and compared with literature values. Differences in values were attributed to substituents in ring positions 3, 4, and 5. Steric hindrance between the pyrazolic nucleus and aromatic substituents and the effect of C-Me groups on shielding of the pyrazolic protons was studied. 85 references. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Electric Literature of C5H7ClN2).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C5H7ClN2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics