Synthesis of heterocyclic systems with a carbohydrate fragment. 1. Stereoselective synthesis of azolo anhydro sugars by addition of azoles to levoglucosenone was written by Samet, A. V.;Laichter, A. L.;Reznikov, D. N.;Yamskov, A. N.;Ugrak, B. I.;Chernyshova, N. B.;Yolkin, V. V.;Semenov, V. V.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1994.Recommanded Product: 5334-39-4 This article mentions the following:
Levoglucosenone (I) reacts with NH-azoles in the presence of bases to give Michael adducts, e.g., II (Az = 3-nitropyrazol-1-yl, 5-nitrotetrazol-2-yl), and in some cases their hydrates (gem-diols) also. In all cases the addition proceeds stereospecifically and with good yields. 3-Nitro-s-triazole, 3- and 4-nitropyrazole, 3-methyl-4-nitropyrazole, 5-nitrotetrazole, 4,5-dicarbomethoxy-v-triazole, 3,4-dinitropyrazole, 3(5)-methylpyrazole, pyrazole and imidazole are used in this reaction. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 5334-39-4).
3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Recommanded Product: 5334-39-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics