Shibamoto, Takayuki published the artcileA Novel Gas Chromatographic Method for Determination of Malondialdehyde from Oxidized DNA, SDS of cas: 930-36-9, the publication is Methods in Molecular Biology (New York, NY, United States) (2015), 49-62, database is CAplus and MEDLINE.
Malondialdehyde (MA) is known to form from various lipids upon oxidation as one of secondary oxidation products. Determination of MA formed from lipid peroxidation has been used to examine occurrence of oxidative damages associated with many diseases, such as cancer, Alzheimer’s, arthritis, inflammation, diabetes, atherosclerosis, and AIDS as well as aging. Anal. of MA is, however, extremely difficult because it is highly reactive and readily polymerized and forming adducts with biol. substances such as proteins, phospholipids, and DNA (Shibamoto, J Pharm Biomed Anal 41:12-25, 2002). Gas chromatog. method using stable derivative, 1-methylpyrazole was advanced and has been successfully used to analyze MA in various lipids and lipid-rich foods. This method was also applied to determine MA formed from DNA and related compounds The amounts found in oxidized 2-deoxyribonucleotides were 213.8 nmol/16 mmol in 2-deoxyguanosine, 130.6 nmol/16 mmol in 2-deoxycytidine, 85.1 nmol/16 mmol in 2-deoxyadenosine, and 84.5 nmol/16 mmol in thymidine. When the antioxidant activity of flavonoids and anthocyanins against calf thymus DNA oxidized with Fenton’s reagent was examined using this newly developed gas chromatog. method, antioxidant activity of flavonoids and anthocyanins ranged from 48.5% (catechin) to 29.9% (apigenin) and from 45.0% (callistephin) to 10.2% (cyaniding), resp.
Methods in Molecular Biology (New York, NY, United States) published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C3H5F3O, SDS of cas: 930-36-9.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics