Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., 5334-40-7
In a 250 mL round bottom flask, 7.0 g (36.6 mmol) of crude I-f was added. 4-nitro-1H-pyrazole-3-carboxylic acid 6.3 g (40.1 mmol), EDC¡¤HCl 8.4 g (44.0 mmol), HOBt 6.0g (44.4mmol) and anhydrous DMF 100mL, Stir at room temperature for 24 h. The disappearance of the starting material by TLC (methanol: chloroform = 1:10). The reaction solution was poured into 200 mL of ice water to precipitate a large amount of pale yellow solid, which was allowed to stand, and a yellow solid was obtained. The obtained crude product was recrystallized from a mixed solvent of ethyl acetate and methanol to give (I-g) 8.6 g (yield: 71.0%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.