Lv, Xunlei published the artcileAssignment of NMR data and Conformational analysis of larotrectinib and its precursors, Related Products of pyrazoles-derivatives, the publication is Tetrahedron (2021), 132064, database is CAplus.
NMR experiments were used to identify the two main conformations of Larotrectinib and its synthetic precursor, the nitro compound 4. Conformational anal. by dynamic NMR was performed in different temperature and solvents, combining 2D EXSY and NOE experiments The results revealed the conformations of Larotrectinib and compound 4 were caused by the barrier to rotation of C11-N17. Meanwhile, the conformational specific structures of compound 4 were postulated based on NOE data and mol. simulation. The complete assignments of 1H and 13C NMR data for compounds 1, 4 and 5 were reported for the first time.
Tetrahedron published new progress about 1363380-51-1. 1363380-51-1 belongs to pyrazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Chloride,Nitro Compound, name is 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine, and the molecular formula is C6H3ClN4O2, Related Products of pyrazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics