Sun, Pengfei published the artcileDMSO-promoted regioselective synthesis of sulfenylated pyrazoles via a radical pathway, Application of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Organic Chemistry Frontiers (2017), 4(7), 1367-1371, database is CAplus.
A green and eco-friendly protocol for the construction of C-4 sulfenylated pyrazoles I [R1 = Me, t-Bu, Ph, COOH; R2 = Me, Ph, 4-MeC6H4, 4-ClC6H4, 2-ClC6H4; R3= Ph, 4-MeC6H4, 4-ClC6H4, etc.; R4 = OH] via a radical pathway was established for the first time. When 1,3-diphenyl-1H-pyrazol-5-amine was reacted with aryl thiols the corresponding 2,5-diphenyl-4-arylsulfanyl-pyrazol-3-amines I [R1 = R2 = Ph; R3 = 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4; R4 = NH2] were also obtained in moderate to good yields. The reaction worked smoothly under catalyst and solvent-free conditions to afford wide range of sulfenylated pyrazole derivatives in good to excellent yields. The thiyl free radical generated in situ, served as a single electron transfer medium for the present transformation. This reaction provided a new strategy for the formation of C-S bond.
Organic Chemistry Frontiers published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C13H10O3, Application of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics