Zhang, Qingwei published the artcileHit to Lead optimization of a novel class of squarate-containing polo-like kinase inhibitors, COA of Formula: C3H5BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(24), 7615-7622, database is CAplus and MEDLINE.
Aminodioxocyclobutenylamino pyrimidineamines (aminopyrimidine squaramides) such as I, derived from a squaramide identified through high-throughput screening, were prepared as selective Polo-like kinase 1 (Plk1) inhibitors for potential use as antitumor agents. Using mol. modeling and extensive structure-activity studies, I (Plk1 Ki = 5 nM; EC50 = 1.05 μM) was identified; its inhibition of Plk1 and of a panel of kinases, its lipophilicity, and its pharmacokinetics were determined I demonstrated moderate efficacy at dosages of 100 mg/kg in a murine pancreatic cancer xenograft tumor model and no overt toxicity.
Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C9H17NO, COA of Formula: C3H5BN2O2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics