Liang, Yanke published the artcileStructure-Activity Relationship study of QL47-a Broad-spectrum Antiviral agent, Recommanded Product: 1H-Pyrazole-4-boronic acid, the publication is ACS Medicinal Chemistry Letters (2017), 8(3), 344-349, database is CAplus and MEDLINE.
Here the authors report the structure-activity relationship (SAR) investigations of QL-XII-47 (QL47), a compound that possesses broad-spectrum antiviral activity against dengue virus and other RNA viruses. A medicinal chem. campaign initiated from QL47, a previously reported covalent BTK inhibitor, to derive YKL-04-085 which is devoid of any kinase activity when screened against a panel of 468 kinases and with imprundooved pharmacokinetic properties. Both QL47 and YKL-04-085 are potent inhibitors of viral translation and exhibit cellular anti-viral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation.
ACS Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Recommanded Product: 1H-Pyrazole-4-boronic acid.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics