Zong, Ziao published the artcileCrystal structures and anticancer activities of five novel pyrazolone-enamine transition metal complexes with 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one, Synthetic Route of 4551-69-3, the publication is Journal of Molecular Structure (2018), 333-339, database is CAplus.
Three pyrazolone-enamine ligands HL1, HL2 and H2L3 were synthesized by the reaction of 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one (HPMBP) with Me 4-aminophenylacetate, 4-aminobenzamide and 2-amino-5-methylphenol, resp., followed by tautomeric reactions. Their complexes [Zn(L1)2] (1), [Co(L2)2(H2O)2] (2), [CuL3(H2O)2] (3a), [ZnL3(H2O)2] (3b) and [CdL3(H2O)2] (3c) were synthesized and characterized by single-crystal x-ray, IR, elemental anal., 1H NMR, TGA. Single-crystal x-ray anal. reveals that HL1, complex 1 and complex 2 are all connected by hydrogen bonds, C-H···π interactions and van der Waals forces to form the 3-D network. The Zn(II) ion in complex 1 is four coordinated to two L1 ligands. The Co(II) ion in complex 2 is six coordinated to two L2 ligands and two water mols. The metal ions in complexes 3a, 3b and 3c are five coordinated to one L3 ligand and two water mols. After coordination, the structures of the ligands reversed to the Schiff base structures. Moreover, the anticancer activities were investigated, complexes 3a and 3b can effectively inhibit the proliferation of human breast cancer MDA-MB-231 cells. Besides, complexes 1, 2, 3b and 3c exhibit excellent luminescence properties.
Journal of Molecular Structure published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C37H30ClIrOP2, Synthetic Route of 4551-69-3.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics