In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 83-10-3 as follows. 83-10-3
Step 8) N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide To a solution of 4-(4-aminophenoxy)-6-methoxyquinolin-7-ol (3.61 g, 12.8 mmol) and 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2.85 g, 12.27 mmol) in DMF (50 mL) was added EDCI (2.81 g, 14.66 mmol) and HOAT (0.33 g, 2.4 mmol). The reaction was stirred at 60 C. for 10 hours, cooled to room temperature and diluted with H2O (200 mL). The solid was collected by filtration and dried in vacuo at 60 C. overnight to give the title compound as a white solid (5.7 g, 89.9%). MS (ESI, pos. ion) m/z: 497.2 [M+1]. 1H NMR (400 MHz, DMSO-d6): delta 10.99 (s, 1H), 10.11 (s, 1H), 7.84-7.82 (d, J=8.76 Hz, 2H), 7.78-7.76 (d, J=7.64 Hz, 2H), 7.62-7.58 (t, J=7.84 Hz, 2H), 7.54-7.46 (m, 2H), 7.46-7.43 (m, 4H), 6.42 (s, 1H), 6.03-6.01 (d, J=7.68 Hz, 1H), 3.85 (s, 3H), 3.37 (s, 3H), 2.72 (s, 3H).
According to the analysis of related databases, 83-10-3, the application of this compound in the production field has become more and more popular.