Lu, Xiaoyun published the artcileDiscovery of new chemical entities as potential leads against Mycobacterium tuberculosis, Product Details of C7H11N3O2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(24), 5916-5919, database is CAplus and MEDLINE.
A series of biheterocyclic (1H-indole, benzofuran, pyrazolo[1,5-a]pyrimidine, pyrazolo[1,5-a]pyrimidin-5(4H)-one, imidazo[2,1-b]thiazole, and pyrazolo[5,1-b]thiazole) derivatives were synthesized and evaluated for their anti-tubercular activities. The imidazo[2,1-b]thiazoles and pyrazolo[5,1-b]thiazoles exhibited promising anti-tubercular activity in varying degrees. Especially, the 2,6-dimethylpyrazolo[5,1-b]thiazole exhibited strong suppressing function against H37Ra strain with MIC value of 0.03 μg/mL. This compound also displayed good pharmacokinetic profiles with oral bioavailability (F) of 41.7% and a half-life of 13.4 h. Furthermore, this compound significantly reduced the bacterial burden in an autoluminescent H37Ra infected mouse model, suggesting its promising potential for development of anti-tubercular drugs.
Bioorganic & Medicinal Chemistry Letters published new progress about 23286-70-6. 23286-70-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Ester, name is Ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate, and the molecular formula is C7H11N3O2, Product Details of C7H11N3O2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics