Feng, Kai-Xiang’s team published research in Organic Letters in 23 | CAS: 14580-22-4

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Synthetic Route of 14580-22-4.

Feng, Kai-Xiang published the artcileEnantioselective Syntheses of C2-Symmetric Pyrazolones and Diones via One-Pot Organo-/Iodine Sequential Catalysis, Synthetic Route of 14580-22-4, the publication is Organic Letters (2021), 23(17), 6750-6755, database is CAplus and MEDLINE.

The catalytic diastereo- and enantioselective synthesis of C2-sym. axially chiral 1,4-dicarbonyl derivatives with 2,3-quaternary stereocenters I (R = 3-bromophenyl, 2-methylphenyl, 3-chlorophenyl; R1 = n-Pr, Ph, naphthalen-1-yl, thiophen-2-yl, etc.; R2 = Et, Pr, i-Pr, cyclopropyl), II (R = i-Pr, 2-fluorophenyl, 2-nitrophenyl, etc.; R2 = Ph, 4-fluorophenyl, 4-bromophenyl, etc.; R3 = Ph, naphthalen-2-yl, furan-2-yl, etc.) and III was achieved by utilizing an organo-/iodine binary catalytic strategy. The reactions proceeded well under mild conditions without metals or strong bases.

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Synthetic Route of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics