Padmaja, Pannala published the artcileSynthesis, molecular docking and in vitro antiproliferative activity of novel pyrano[3,2-c]carbazole derivatives, Recommanded Product: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is New Journal of Chemistry (2016), 40(10), 8305-8315, database is CAplus.
A new series of polycyclic pyrano[3,2-c]carbazole derivatives have been synthesized by domino Knoevenagel-hetero-Diels-Alder reactions. The key strategy involves ethylenediamine diacetate (EDDA) catalyzed cyclization of the O-prenyl derivative of N-Boc-carbazole-3-carboxaldehyde with cyclic 1,3-diketones or pyrazol-5-ones to afford cis-fused N-Boc-pyrano[3,2-c]carbazole derivatives The reactions were clean and highly diastereoselective, affording the desired products in good yields. The deprotection of the Boc group under acidic conditions led to pyrano[3,2-c]carbazole derivatives The antiproliferative activity of all the synthesized compounds on three cancer cell lines such as PANC 1 (pancreatic), HeLa (cervical) and MDA-MB-231 (breast cancer) was investigated. Three compounds including I displayed pronounced antiproliferative activity. The antimicrobial activity of these compounds was assayed against three representative Gram-pos. organisms and Gram-neg. organisms. Compound I exhibited significant antimicrobial activity. Mol. docking studies revealed that the lead compounds selectively occupy the colchicine binding site of tubulin.
New Journal of Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Recommanded Product: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics