139756-02-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139756-02-8 as follows.
Preparation 20: 4-(3, 4-Dimethoxyphenylcarboxamido)-1-methyl-3-propyl-lH-5-pyrazolecarboxamide A mixture of 4-amino-l-methyl-3-propyl-lH-5-pyrazolecarboxmide (19.57g, 107.5 mmol) and triethylamine (54.4g, 134.38 mmol) in dichloromethane (300 mL) were taken in a 1 liter 3 neck round bottom flask fitted with a nitrogen balloon, pressure equalizing addition funnel and a septum. To the mixture was added a solution of 3, 4-dimethoxy-1- benzenecarbonylchloride (21. 5g, 107. 5mmol) in dichloromethane (lOOmL) at 0 C through a pressure equalizing addition funnel over a period of 0.5 h under nitrogen atmosphere. The reaction temperature was raised to 25 C after addition and the contents were stirred for another 12 h. Dichloromethane was removed from the reaction mixture under reduced pressure and the solid obtained was washed with cold water (2 x 150 mL), filtered and dried under vacuum to get the title compound 33g, (89 %) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 139756-02-8, and friends who are interested can also refer to it.