Yang, Shu-Wei published the artcileBenzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus, Safety of 1H-Pyrazole-4-boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(19), 4743-4747, database is CAplus and MEDLINE.
A series of benzimidazole analogs have been synthesized to improve the profile of the previous lead compounds tarocin B. The syntheses, structure-activity relationships, and selected biochem. data of these analogs are described. The optimization efforts allowed the identification of I, a fluoro-substituted benzimidazole, exhibiting potent TarO inhibitory activity and typical profile for a wall teichoic acid (WTA) biosynthesis inhibitor. Compound I displayed a potent synergistic and bactericidal effect in combination with imipenem against diverse methicillin-resistant Staphylococci.
Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C5H7BO2S, Safety of 1H-Pyrazole-4-boronic acid.
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https://en.wikipedia.org/wiki/Pyrazole,
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