Thach, Thi-Dan published the artcileSynthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents, HPLC of Formula: 71203-35-5, the publication is Journal of the Serbian Chemical Society (2020), 85(2), 155-162, database is CAplus.
Two series of sulfonamides were synthesized from 4-hydrazinylbenzenesulfonamide as the key starting material. 1,3,5-triarylpyrazoline sulfonamides I [R = H, F, MeO; Ar = Ph, 4-MeC6H4, 2-HOC6H4, 4-MeOC6H4] were obtained by cyclocondensation of various chalcones in 53-64% yields, while 4-thiazolidinone derivatives II [Ar1 = Ph, 4-MeC6H4, 2-HOC6H4, 4-ClC6H4, 4-MeOC6H4] were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62% yields. The synthesized compounds were characterized based on FTIR, 1H-NMR, 13C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. niger (MIC value at 12.5μg mL-1) over the reference drug.
Journal of the Serbian Chemical Society published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C9H8O4, HPLC of Formula: 71203-35-5.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics