Waterson, Alex G. published the artcileDiphenylpyrazoles as replication protein A inhibitors, Synthetic Route of 13599-22-9, the publication is ACS Medicinal Chemistry Letters (2015), 6(2), 140-145, database is CAplus and MEDLINE.
Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N). Here the authors describe the optimization of a diphenylpyrazole carboxylic acid series of inhibitors of these RPA-protein interactions. The authors evaluated substituents on the aromatic rings as well as the type and geometry of the linkers used to combine fragments, ultimately leading to submicromolar inhibitors of RPA70N protein-protein interactions.
ACS Medicinal Chemistry Letters published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C7H7BN2O2, Synthetic Route of 13599-22-9.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics