Pahontu, Elena published the artcileSynthesis, characterization, crystal structure and antiproliferative activity studies of Cu(II), Ni(II) and Co(II) complexes with 4-benzoyl-5-pyrazolones derived compounds, Category: pyrazoles-derivatives, the publication is Journal of Organometallic Chemistry (2017), 44-55, database is CAplus.
Eleven new Cu(II), Ni(II), and Co(II) complexes (1–11) with thiosemicarbazones 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone-4-R thiosemicarbazone (R = CH3,C6H5, C5H5N) (HL1-3) were synthesized. The ligands was characterized by FT- IR, 1H NMR, 13C NMR spectroscopy and x-ray diffraction. All the complexes were characterized by UV-visible and FTIR spectroscopy, molar conductivity, magnetic susceptibility measurements and elemental anal. The Cu (II) complexes were studied by EPR spectroscopy. Also, the crystal structures of copper and nickel complexes 1, 3, 6 and 7 were determined by single-crystal x-ray diffraction anal. The Cu atom exhibits a distorted square-planar coordination environment in the complex 1 provided by one mol. of deprotonated ligand and one chloride anion, while in the complex 6 show a distorted square-pyramidal coordination geometry. In the complexes 3 and 7, the Ni atom exhibits a slightly distorted octahedral O2N2S2 coordination provided by two mols. of tridentate deprotonated ligand. The in vitro antiproliferative activity of the ligands and metal complexes was screened on human leukemia HL-60 cells. It was noticed a significant inhibition of growth of malignant cells HL-60 in the case Cu complexes 2 and 5 with IC50 values of 0.24 μM and 0.36 μM, resp.
Journal of Organometallic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics