Brzozowski, Zdzislaw’s team published research in Acta Poloniae Pharmaceutica in 38 | CAS: 53355-55-8

Acta Poloniae Pharmaceutica published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Synthetic Route of 53355-55-8.

Brzozowski, Zdzislaw published the artcileDerivatives of pyrazole-1-carboxylic acid. II. Synthesis of certain 4-[2-(1-pyrazolecarboxamido)ethyl]benzenesulfonamides, Synthetic Route of 53355-55-8, the publication is Acta Poloniae Pharmaceutica (1981), 38(4), 399-405, database is CAplus.

Fifteen title compounds (I, R = H, Me, Et; R1 = H, Me, Et, Pr, Bu, PhCH2, Cl; R2 = H, Me) were prepared in 55-91% yields from the corresponding 1-pyrazolecarbonyl chlorides and 4-H2NSO2C6H4(CH2)2NH2 in Et3N (or NaOH in aqueous Me2CO). Some I were also obtained in the reaction of 4-H2NSO2C6H4(CH2)2NHCONHNH2 (II) with BzOCH:CR1COR in AcOH. I (R = Me, R1 = R2 = H) was addnl. prepared also from II and MeCOCH2CH(OEt)2. To prepare II, I (R = R2 = Me, R1 = H) was heated with N2H4 in EtOH.

Acta Poloniae Pharmaceutica published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Synthetic Route of 53355-55-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics