Wang, Gang published the artcileSynthesis, structure characterization and antibacterial activities of the Schiff base condensed from 1-phenyl-3-methyl-4-(p-methylbenzoyl)-5-pyrazolone and L-phenylane ethyl ester and its metal complexes, Computed Properties of 4551-69-3, the publication is Xinxiang Yixueyuan Xuebao (2015), 32(1), 8-11, database is CAplus.
The aim of the research was to synthesize a Schiff base derived from 1-phenyl-3-methyl-4-(p-methylbenzoyl)-5-pyrazolone (HPMTP) with L-phenylane Et ester and its metal complexes [Cu (II), Co (II), Ni (II), Fe (II), Mn (II)] and test their possible structures and antibacterial activity. The possible structures were given to the six compounds by elemental anal., 1H NMR (1H NMR) and IR spectroscopy (IR) methods. The antibacterial activity tests at different concentrations against E. coli and B. subtilis were performed using diffusion test in vitro. The possible structure of schiff base ligand and its metal complexes was deduced according to the results of 1H-NMR and IR. All compounds had the activity of inhibiting the growth of the E. coli and B. subtilis at 1.25, 2.50, 5.00 g·L-1, and the antibacterial activity was the highest at 2.50 g·L-1. The order of the antibacterial activity was metal complex > Schiff base ligand > HPMTP. Especially, the antibacterial activity of Cu (II) and Co (II) complexes was the best. Cu (II) and Co (II) complexes were worth for them to be future developed.
Xinxiang Yixueyuan Xuebao published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H21BO2Si, Computed Properties of 4551-69-3.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics