Zhou, Zhen published the artcile4-Benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one/PdCl2-catalyzed Suzuki coupling reactions under mild aerobic conditions, Quality Control of 4551-69-3, the publication is Huaxue Tongbao (2016), 79(3), 243-247, database is CAplus.
A simple com. ligand 4-benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one had been applied to the palladium-catalyzed Suzuki-Miyaura cross-coupling in this paper. The effect of reaction condition, such as temperature, time, solvents and bases on the yield of product had been evaluated. Under the optimized conditions, a variety of aryl bromides and phenylboronic acid were successfully cross-coupled in high yield at a low catalytic loading of 0.1 (mol)%. Furthermore, the less reactive reactants such as aryl chlorides was explored to enlarge the scope of this cross-coupling, and it was found that the catalytic system employing the ligand in DMF/H2O provided a general and convenient method to prepare biaryls from activated aryl chlorides. Besides, the optimal experiments revealed that the improvement of reaction time/temperature as well as the polarity of the proton solvent turned out to be the effective method for the coupling reaction.
Huaxue Tongbao published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C18H28BNO2, Quality Control of 4551-69-3.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics