Toutov, Anton A. published the artcileSilylation of C-H bonds in aromatic heterocycles by an Earth-abundant metal catalyst, Product Details of C4H6N2, the publication is Nature (London, United Kingdom) (2015), 518(7537), 80-84, database is CAplus and MEDLINE.
Heteroaromatic compounds containing C-Si (C-Si) bonds are of great interest in the fields of organic electronics and photonics, drug discovery, nuclear medicine and complex mol. synthesis, because these compounds have very useful physicochem. properties. Many of the methods now used to construct heteroaromatic C-Si bonds involve stoichiometric reactions between heteroaryl organometallic species and Si electrophiles or direct, transition-metal-catalyzed intermol. C-H (C-H) silylation using Rh or Ir complexes in the presence of excess H acceptors. Both approaches are useful, but their limitations include functional group incompatibility, narrow scope of application, high cost and low availability of the catalysts, and unproven scalability. For this reason, a new and general catalytic approach to heteroaromatic C-Si bond construction that avoids such limitations is highly desirable. Here the authors report an example of cross-dehydrogenative heteroaromatic C-H functionalization catalyzed by an Earth-abundant alkali metal species. Readily available and inexpensive K tert-butoxide catalyzes the direct silylation of aromatic heterocycles with hydrosilanes, furnishing heteroarylsilanes in a single step. The silylation proceeds under mild conditions, in the absence of H acceptors, ligands or additives, and is scalable to >100 g under optionally solvent-free conditions. Substrate classes that are difficult to activate with precious metal catalysts are silylated in good yield and with excellent regioselectivity. The derived heteroarylsilane products readily engage in versatile transformations enabling new synthetic strategies for heteroaromatic elaboration, and are useful in their own right in pharmaceutical and materials science applications.
Nature (London, United Kingdom) published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C6H10N2, Product Details of C4H6N2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics