Zhang, Qiangsheng’s team published research in Chemical Communications (Cambridge, United Kingdom) in 57 | CAS: 23286-70-6

Chemical Communications (Cambridge, United Kingdom) published new progress about 23286-70-6. 23286-70-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Ester, name is Ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate, and the molecular formula is C7H6N2O2S, COA of Formula: C7H11N3O2.

Zhang, Qiangsheng published the artcileThe discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor, COA of Formula: C7H11N3O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(24), 3006-3009, database is CAplus and MEDLINE.

By targeting the unique Cys663 of EZH2, SKLB-0335 displayed high paralog-selectivity on EZH2. Biochem. studies showed that SKLB-0335 was covalently bind to EZH2 at its S-adenosylmethionine (SAM) pocket and inhibited H3K27Me3. SKLB-0335 was an effective chem. probe with which to further investigate the specific biol. functions of EZH2.

Chemical Communications (Cambridge, United Kingdom) published new progress about 23286-70-6. 23286-70-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Ester, name is Ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate, and the molecular formula is C7H6N2O2S, COA of Formula: C7H11N3O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics