Wang, Yuting published the artcileDesign, synthesis, and biological evaluation of pyrano[2,3-c]pyrazole-Based RalA inhibitors against hepatocellular carcinoma, Computed Properties of 14580-22-4, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2021), 700956, database is CAplus and MEDLINE.
The discovery of a series of 6-sulfonylamide-pyrano[2,3-c]pyrazole derivatives I [R = H, 4-Me, 2-MeO, etc.; R1 = C6H5, 4-MeC6H4, 4-MeOC6H4, etc.; R2 = C6H5, 4-MeC6H4, 3-MeOC6H4, etc.] as novel RalA inhibitors was reported. ELISA-based biochem. assay results indicated that compounds I [R = H; R1 = 4-MeC6H4, 4-MeOC6H4, 4-F3CC6H4, 2,4-di-FC6H3, 2-thienyl; R2 = 4-F3CC6H4, 3-pyridyl, 4-pyridyl, 3-thienyl] suppressed RalA/B binding capacities to their substrates. Cellular proliferation assays indicated that these RalA inhibitors potently inhibited the proliferation of HCC cell lines, including HepG2, SMMC-7721, Hep3B, and Huh-7 cells. Among the evaluated compounds, compound I [R = H, R1 = 4-MeOC6H4, R2 = 4-F3CC6H4] displayed good inhibitory capacities on RalA (IC50 = 0.22渭M) and HepG2 cells (IC50 = 2.28渭M). Overall, the results suggested that a novel small mol. RalA inhibitor with a 6-sulfonylamide-pyrano[2,3-c]-pyrazole scaffold suppressed autophagy and cell proliferation in hepatocellular carcinoma, and that it has potential for HCC-targeted therapy.
Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C3H6O2, Computed Properties of 14580-22-4.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics