Guha, Rajarshi published the artcileRanking differential drug activities from dose-response synthetic lethality screens, Category: pyrazoles-derivatives, the publication is Journal of Biomolecular Screening (2016), 21(9), 942-955, database is CAplus and MEDLINE.
Synthetic lethal screens are used to discover new combination treatments for cancer. In traditional high-throughput synthetic lethal screens, compounds are tested at a single dose, and hit selection is based on threshold activity values from the variance of the efficacy of the compounds tested. The limitation of the single-dose screening for synthetic lethal screens is that it does not allow for the robust detection of differential activities from compound collections with a broad range of potencies and efficacies. There is therefore a need to develop screening approaches that enable the identification of compounds with synthetic lethal effects based on changes in both potency and efficacy. Here we describe the implementation of a dose response-based synthetic lethal screen to find drugs that enhance or mitigate the cytotoxic effect of an immunotoxin protein (HA22). We developed a data anal. framework for the selection of compounds with enhancing or mitigating cytotoxic activities based on the use of dose-response parameters. The data anal. framework includes an ensemble ranking approach that allows the use of multiple dose-response parameters in a nonparametric fashion. Quant. high-throughput screening (HTS) enables the identification of compounds with synthetic lethal activity not identified by single-dose HTS.
Journal of Biomolecular Screening published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, Category: pyrazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics