Bauer, Udo published the artcileDiscovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors, Application In Synthesis of 763120-58-7, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(5), 1944-1948, database is CAplus and MEDLINE.
A series of 1,6-naphthyridine-based compounds, e.g., I (R1 = OEt, Cl, CH2OH, morpholinomethyl, etc.), was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. For example, (bromophenyl)naphthyridinecarbonitrile II reacted with [2-(trifluoromethoxy)phenyl]boronic acid in the presence of PPh3/Pd(OAc)2/Na2CO3 in THF/H2O and heated for 30 min to 150°C in a microwave oven to give the biphenyl naphthyridine III. Structure-based chem. modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.
Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Application In Synthesis of 763120-58-7.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics