39806-90-1, A common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of intermediate 21.2 (250 mg, 0.754 mmol) and 4-iodo-l-methyl-lH-pyrazole (204 mg, 0.981 mmol) in anhydrous Dioxane (3 mL) was added (/ra/ v)-N i.N2-dimethylcyclohexane- 1, 2-diamine (42.9 mg, 0.302 mmol), potassium phosphate (480 mg, 2.263 mmol) and Cul (28.7 mg, 0.151 mmol). The resulting mixture was stirred at 90C for 16 hours under N2 protection . After filtration and evaporation, the crude residue was purified by silica gel column chromatography (gradient eluent of 0% to 21% EtO Ac/Petroleum ether) to give intermediate 21.3, ( R,R and 5′,5′)-tert-butyl 3-hydroxy-4-(5-methyl-l-(l-methyl-lH-pyrazol-4-yl)-lH-indazol-6- yl)piperidine-l -carboxylate. MS (ESI) m/z calc?d for C22H30N5O3 [M+H]+ 412, found 412.
The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.