Akhrem, A. A. et al. published their research in Zhurnal Obshchei Khimii in 1975 | CAS: 61453-49-4

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Product Details of 61453-49-4

Reaction of diazoacetic ester with propargyl acetate was written by Akhrem, A. A.;Kvasyuk, E. I.;Mikhailopulo, I. A.. And the article was included in Zhurnal Obshchei Khimii in 1975.Product Details of 61453-49-4 The following contents are mentioned in the article:

Cyclization of HCCCH2OAc and N2CHCO2Et in refluxing toluene gave the isomeric pyrazolecarboxylates I and II. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Product Details of 61453-49-4).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Product Details of 61453-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics