Akhrem, A. A. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1976 | CAS: 61453-49-4

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 61453-49-4

Synthesis of isomeric pyrazoles by the reaction of propargyl acetate with alkyl diazoacetates was written by Akhrem, A. A.;Kvasyuk, E. I.;Mikhailopulo, I. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1976.HPLC of Formula: 61453-49-4 The following contents are mentioned in the article:

Isomeric pyrazoles I, II (R = Et, Me) were obtained by cyclization of HCCCH2OAc with N2CHCO2R. Hydrolysis of I, II (R = Et) led to the corresponding deacetylated esters. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4HPLC of Formula: 61453-49-4).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 61453-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics