Kobayashi, Keijiro et al. published their research in Chemistry Letters in 2007 | CAS: 61453-49-4

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate

1,3-Dipolar cycloaddition of ethyl diazoacetate to alkynes in the pores of zeolite NaY was written by Kobayashi, Keijiro;Igura, Yuta;Imachi, Shouhei;Masui, Yoichi;Onaka, Makoto. And the article was included in Chemistry Letters in 2007.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

Zeolite NaY promotes 1,3-dipolar cycloaddition of Et diazoacetate to alkynes having an electron-withdrawing group to afford the corresponding functionalized pyrazoles in high yields. The activation of the dipolarophile inside the pores of NaY is proposed based on the 13C MAS NMR anal. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics